Preparative supercritical fluid chromatography

Preparative Supercritical Fluid Chromatography

Supercritical Suid chromatography (SFC) on a preparative scale is of interest because of its advantages over high performance liquid chromatography (HPLC). The high diffusivity and low viscosity of supercritical Suids allow rapid separation. The solvent strength can easily be controlled by changing pressure and/or temperature, so that mobile phases with a Rxed composition can be used to separat...

Supercritical Fluid Extraction+supercritical Fluid Chromatography

high pressures also requires special equipment. In summary, both RESS crystallization and SAS crystallization appear to be promising methods for generating supersaturation and therefore represent alternatives to conventional crystallization. Such alternatives may prove attractive in applications such as polymer and pharmaceutical processing, or in particle design for drug delivery. It is possib...

Supercritical Fluid Chromatography

(1995) Journal of Chromatography A 691: 239}246. [43] LeBelle M, Pike RK, Graham SJ, Ormsby ED and Bogard H (1996) Journal of Pharmaceutical and Biomedical Analysis 14: 793}800. [44] Bernal JL, del Nozal MJ, Martin MT and Diez-Masa JC and Cifuentes (1998) Journal of Chromatography A 823: 423}431. [45] Polettini A, Bouland GM and Montagna M (1998) Journal of Chromatography B: Biomedical Sciences...

Supercritical Fluid Chromatography

Since there is an enormous volume of information on the separation of antibiotics in the literature, readers should be able to Rnd HPLC conditions for almost any antibiotic of interest. Readers are also encouraged to consult the ofRcial compendia for analysis of bulk or formulated drugs. For analysis of biological samples, the samples may be directly injected with a column switching technique i...

Supercritical Fluid Chromatography